Unwanted by his parents, fourteen-year-old Cosmo Hill escapes from his abusive orphanage and is put to work by the state, testing highly dangerous products. Cosmo realizes he must get away, and escapes with the help of the Supernaturalists, a group of kids who have the same special abilities as Cosmo - they can see supernatural Parasites, creatures that feed on the life force of humans.

The Supernaturalists patrol the city at night, hunting the Parasites in hopes of saving what is left of humanity in Satellite City. But soon they find themselves caught in a web far more complicated than they'd imagined, and they discover a horrifying secret that will force them to question everything they believe in.